With the recent advances of nanotechnology, we develop novel techniques for the diagnosis and treatment of high impact diseases such as Alzheimer and other neurological disorders.
Detection of molecules is central to medical diagnostics. Ideally, they should develop miniaturized detection devices, highly biocompatible and freelancers. This requires work with platforms that provide real-time response to stimuli of relatively low magnitude. Additionally, to achieve miniaturization and implantation, it is essential that detection events occur on thin, flexible material. Graphene, meets the ideal characteristics for the manufacture of these devices: it has electrical properties that allow it to provide ultra-fast responses, its size and topology allow access to extremely small sizes and is made of carbon, a highly biocompatible material. Given the versatility of graphene, it is possible to use methods of transduction of various kinds including refractometric, colorimetric and fluorometric among many others.
In this area of work, the group is dedicated to the engineering of nanosystems for delivery of therapeutic molecules. This work is based on the developments of the Neuroscience Group of Antioquia in gene therapies based on RNA interference. The idea is to provide a nanoformulación that can easily enter and neuronal cells in a highly specific and controlled safe mute the synthesis of proteins that are involved in Alzheimer's. This is expected to lead to highly specific treatments requiring fewer doses and consequently produce fewer side effects.
Some major events in Alzheimer's are mediated by membrane proteins. The understanding of these events, it is vital for the development of highly effective therapeutic strategies. Our aim is to determine accurately and quantitatively the level of interaction of membrane proteins of interest. In the long term it is expected to have a detailed map of interactions that allow a rational design approach to gene therapy. These interactions will be measured with the help of spectrophotometric techniques and microscopy based on Forster Resonance Energy Transfer (FRET). These developments will be carried out both in model lipid bilayers and in living cells.